A royal from a sacred tribe combines Qing Nang Shu with Eastern and Western practices to cure the sick and save the dying. Mu Xing Chen who comes from the Shen Mu Tribe has been studying medicine for years. When Ye Yun Shang, a young woman from a family of doctors, barges into their territory, he saves her from trouble and ends up running away with her. Wanting to escape the politics within his family, Xing Chen tries his luck in the normal world. His journey takes him to a place afflicted by a rare kind of the plague. Despite the trials, he goes on a road to becoming a master of medicine all whilst finding love.